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Diabetics taking Glucophage to control blood sugar levels are encouraged to discuss a serious, often fatal side effect with their physician. When this medicine is inappropriately prescribed, it can cause a potentially fatal build-up of lactic acid in the blood. The Journal of the American Medical Association recently reported findings that suggest some doctors may be unaware of the drug's warnings against use by patients with kidney disease, those who are taking medicine for heart failure, or when the patient is having a CT scan performed with IV contrast.